Scientists Report that Drinking Baking Soda Could Be a Cheap and Safe Way to Combat Autoimmune Disease and Inflammatory Problems

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A daily dose of baking soda may help reduce the destructive inflammation of autoimmune diseases like rheumatoid arthritis. Researchers observed human and animal models and found that after drinking water with baking soda for two weeks, the population of  waste-consuming immune cells called macrophages shifted from mostly those that promote inflammation to those that reduce it. The shift from inflammatory to an anti-inflammatory profile was observed throughout the body, including the kidneys, the spleen, and in the peripheral blood. The article states that the dosage people take daily for alkalinizing their body’s pH, or for use as an antacid, is one-half to 1 teaspoon of baking soda completely dissolved in at least 4 ounces of water. Some health advocates recommend using aluminum-free baking soda.

A daily dose of baking soda may help reduce the destructive inflammation of autoimmune diseases like rheumatoid arthritis, scientists say.

They have some of the first evidence of how the cheap, over-the-counter antacid can encourage our spleen to promote an anti-inflammatory environment that could be therapeutic in the face of inflammatory disease, Medical College of Georgia scientists report in the Journal of Immunology.

They have shown that when rats or healthy people drink a solution of baking soda, or sodium bicarbonate, it becomes a trigger for the stomach to make more acid that can digest the next meal.

It also gets little-studied mesothelial cells sitting on the spleen to tell the fist-sized organ that there’s no need to mount a protective immune response.

Dr. Paul O’Connor, who is a renal physiologist and the study’s corresponding author, says that it’s sort of reassuring our organs that “it’s most likely a hamburger, not a bacterial infection.”

The mesothelial cells that line body cavities, like the one that contains our digestive tract, cover the exterior of our organs to quite literally keep them from rubbing together. About a decade ago, it was found that these cells also provide another level of protection; they have little fingers, called microvilli, that sense the environment, and warn the organs they cover that there is an invader and an immune response is needed.

Drinking baking soda, the MCG scientists think, tells the spleen – which is part of the immune system – to go easy on the immune response.

“Certainly drinking bicarbonate affects the spleen and we think it’s through the mesothelial cells,” O’Connor says.

The dosage people take daily for alkalinizing their body’s pH, or for use as an antacid, is one-half to 1 teaspoon of baking soda completely dissolved in at least 4 ounces of water.

The conversation, which occurs with the help of the chemical messenger acetylcholine, appears to promote a landscape that shifts against inflammation, they report.

In the spleen, as well as the blood and kidneys, they found after drinking water with baking soda for two weeks, the population of immune cells called macrophages, shifted from primarily those that promote inflammation, called M1, to those that reduce it, called M2. Macrophages, perhaps best known for their ability to consume garbage in the body like debris from injured or dead cells, are early arrivers to a call for an immune response.

In the case of the lab animals, the problems were hypertension and chronic kidney disease, problems which got O’Connor’s lab thinking about baking soda.

One of the many functions of the kidneys is balancing important compounds like acid, potassium and sodium. With kidney disease, there is impaired kidney function and one of the resulting problems can be that the blood becomes too acidic, O’Connor says. Significant consequences can include increased risk of cardiovascular disease and osteoporosis.

“It sets the whole system up to fail basically,” O’Connor says. Clinical trials have shown that a daily dose of baking soda can not only reduce acidity, but actually slow progression of the kidney disease, and it’s now a therapy offered to patients.

“[So] we started thinking, how does baking soda slow progression of kidney disease?” O’Connor says.

That’s when the anti-inflammatory impact began to unfold as they saw reduced numbers of M1s and increased M2s in their kidney disease model after consuming the common compound.

When they looked at a rat model without actual kidney damage, they saw the same response. So the basic scientists worked with the investigators at MCG’s Georgia Prevention Institute to bring in healthy medical students who drank baking soda in a bottle of water and also had a similar response.

“The shift from inflammatory to an anti-inflammatory profile is happening everywhere,” O’Connor says. “We saw it in the kidneys, we saw it in the spleen, now we see it in the peripheral blood.”

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Tom Cornwell
Tom Cornwell
8 months ago

When I started reading this article I was very pleased and encouraged. When I read the plug for Bob’s Red Mill I was less so, since there is no aluminum in any brand of baking soda, nor in its manufacture. This has been a marketing ploy of Bob’s for many years…taking advantage of the confusion between baking soda and baking powder, some of which does use aluminum. Time to scold one of your editors Ed.

timo
timo
8 months ago

Is this not just a fake news story? Basic chemistry 101 bicarbonate of soda neutralises stomach acid so how does it pass the digestive system in order to have any effect?

Bryan
Bryan
8 months ago

I use baking soda, to manage gout (about 1/2 tsp mixed in water, 1 – 2 times per day, when needed). If you use baking soda, regularly, as a medicine, you’ll want to watch out, for symptoms of a vitamin B2 deficiency. It turns out, that baking soda neutralizes B2 (riboflavin), in the body. I don’t notice any problems, when I use it for one or two days, but if I use it for several days in a row, I’ll start noticing signs of a B2 deficiency, like a sore throat, and cracks on the sides of my lips. Taking… Read more »